Caputi M, Esposito V, Groger A M, De Luca A, Pacilio C, Dekan G, Giordano G G, Baldi F, Wolner E, Giordano A
Department of Respiratory Diseases, II University of Naples, Italy.
Anticancer Res. 1998 Jul-Aug;18(4A):2371-4.
We evaluated the expression of pRb by immunohistochemistry in 98 lung cancer specimens already characterized for their p16 and cyclin D1 status. We found the absence of pRb expression to be dependent upon the histological type, being more frequent in SCLCs than in NSCLCs (p < .00005). On the other hand, we failed to find any correlation between the expression of pRb and p16. In addition, we found a positive correlation between the expression of pRb and cyclin D1 (p = .0001). Therefore, we hypothesize that pRb growth control may be overcome by two different mechanisms in lung carcinogenesis: loss of pRb expression or overexpression of cyclin D1.
我们通过免疫组织化学方法评估了98例已明确p16和细胞周期蛋白D1状态的肺癌标本中pRb的表达情况。我们发现pRb表达缺失取决于组织学类型，在小细胞肺癌中比在非小细胞肺癌中更常见（p <.00005）。另一方面，我们未发现pRb表达与p16之间存在任何相关性。此外，我们发现pRb表达与细胞周期蛋白D1之间存在正相关（p =.0001）。因此，我们推测在肺癌发生过程中，pRb生长控制可能通过两种不同机制被克服：pRb表达缺失或细胞周期蛋白D1过表达。
