Olderøy G, Daehlin L, Ogreid D
Center for Molecular Medicine, Haukeland Hospital, Bergen, Norway.
Anticancer Res. 1998 Jul-Aug;18(4A):2675-8.
BACKGROUND, PATIENTS AND METHODS: The objective was to study the frequency of mutations of Ha-ras and Ki-ras oncogenes in bladder tumours. Transitional cell tumours of the bladder from 55 patients were subjected to analyses of Ha-ras and Ki-ras oncogenes using a variety of techniques including sequencing to detect mutations.
Two tumours (4%) exhibited mutation of the Ki-ras oncogene, both tumours were fast growing and invasive. We did not detect Ha-ras mutation in any of the samples. Nineteen tumours (35%) with established invasion of the detrusor muscle, did not reveal any mutation.
Analyses of ras oncogenes seem to be of limited value for the biological assessment of transitional cell carcinomas.
背景、患者与方法：目的是研究膀胱肿瘤中Ha-ras和Ki-ras癌基因的突变频率。对55例患者的膀胱移行细胞肿瘤采用包括测序在内的多种技术进行Ha-ras和Ki-ras癌基因分析以检测突变。
2例肿瘤（4%）表现出Ki-ras癌基因突变，这2例肿瘤均生长迅速且具有侵袭性。我们在任何样本中均未检测到Ha-ras突变。19例（35%）已证实有逼尿肌浸润的肿瘤未显示任何突变。
ras癌基因分析对移行细胞癌的生物学评估似乎价值有限。
