Sharma V, Xu M, Ritter L M
Department of Biology, University of West Florida, Pensacola 32514, USA.
Biochem Biophys Res Commun. 1998 Jul 30;248(3):716-21. doi: 10.1006/bbrc.1998.9045.
A family of hematopoietic specific transcription factors, MIP-1 alpha nuclear protein (MNP) family, has recently been identified. They are intimately involved in regulating the transcription of the huMIP-1 alpha gene in monocytes, T-cells, and transformed B-cells. One member of the family (MNP-1) is essential for promoter activity in monocytes and B-cells, while another (MNP-2) is required for full promotor activity in T-cells. A third member of the family (MNP-3) is expressed in PMA induced HL60 cells and probably has a role in monocyte differentiation. In this communication we demonstrate by two techniques that MNP-1 and MNP-2 are distinct but related factors, and we present further evidence to show that MNP-1 acts as a heterodimer.
最近发现了一个造血特异性转录因子家族，即MIP-1α核蛋白（MNP）家族。它们密切参与调节单核细胞、T细胞和转化B细胞中huMIP-1α基因的转录。该家族的一个成员（MNP-1）对单核细胞和B细胞中的启动子活性至关重要，而另一个成员（MNP-2）是T细胞中完全启动子活性所必需的。该家族的第三个成员（MNP-3）在佛波酯诱导的HL60细胞中表达，可能在单核细胞分化中起作用。在本通讯中，我们通过两种技术证明MNP-1和MNP-2是不同但相关的因子，并提供进一步证据表明MNP-1作为异二聚体发挥作用。
