DeSilva T N, Kress D W
Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania, USA.
Dermatol Clin. 1998 Jul;16(3):579-92. doi: 10.1016/s0733-8635(05)70254-0.
Collagen vascular diseases seen in children include systemic, discoid and neonatal lupus, dermatomyositis, scleroderma, juvenile rheumatoid arthritis, and, in rare cases, Sjogren's syndrome. Although these diseases are uncommon in children, when seen, they are associated with significant morbidity. This review describes the clinical features of each condition and provides an overview of treatment options now available. These include numerous systemic treatments which can be used as steroid-sparing agents.
儿童中可见的胶原血管疾病包括系统性红斑狼疮、盘状红斑狼疮和新生儿红斑狼疮、皮肌炎、硬皮病、幼年类风湿关节炎，以及罕见的干燥综合征。尽管这些疾病在儿童中并不常见，但一旦出现，往往伴随着严重的发病率。这篇综述描述了每种疾病的临床特征，并概述了目前可用的治疗选择。这些包括许多可作为类固醇替代药物使用的全身治疗方法。
