Ganchev T, Mileva V, Velikova M, Georgieva M
Department of Physiology, Medical University, Varna, Bulgaria.
Haematologia (Budap). 1998;29(1):33-9.
The aim of our investigations was to define the influence of reserpine on iron absorption in rats. Iron absorption was determined in vivo at the 24th hour and in situ in a tied-off intestinal segment. Five-days treatment with reserpine (1 mg/kg b.wt) led to suppressed bone marrow erythropoiesis, manifested a considerable decrease in reticulocyte count and in a percentage of 59Fe-incorporation into newly formed erythrocytes. Increased plasma iron and decreased plasma ferritin levels were found. Iron absorption was found to be significantly increased, in spite of the suppressed erythropoiesis. The major conclusions of the experiments are, that reserpine interferes with the regulation of iron metabolism and erythropoiesis.
我们研究的目的是确定利血平对大鼠铁吸收的影响。在第24小时于体内以及在结扎的肠段中原位测定铁吸收。用利血平（1毫克/千克体重）进行为期五天的治疗导致骨髓红细胞生成受到抑制，表现为网织红细胞计数以及59Fe掺入新形成红细胞的百分比显著降低。发现血浆铁水平升高而血浆铁蛋白水平降低。尽管红细胞生成受到抑制，但铁吸收仍显著增加。实验的主要结论是，利血平干扰铁代谢和红细胞生成的调节。
