He Q, Ohaki Y, Mori O, Asano G, Tuboi N
Department of Pathology, Nippon Medical School Chiba Hokusou Hospital, Tokyo, Japan.
Pathol Int. 1998 May;48(5):416-20. doi: 10.1111/j.1440-1827.1998.tb03926.x.
This report describes a renal tumor with an unusual histology in a 45-year-old woman. The tumor was white in color, different from usual renal cell carcinoma, and mainly consisted of variously shaped tubules formed by flat or cuboid cells within marked edematous stroma. Elaborated branching or tubules arranged in a papillary pattern with focal spindle-shaped cell proliferation were characteristic features. Immunohistochemical staining expressed diffusely positive for vimentin and S-100 protein, partially positive for cytokeratin and epithelial membrane antigen and negative for Leu-M1, Leu-7, CD34 and markers for muscle cells. Ultrastructural studies of the tumor cells showed adenocarcinoma-like characteristics. According to these histological, immunohistochemical and electron microscopy findings, it is suggested that this tumor be designated as unclassified renal cell carcinoma with histology mimicking lower-nephron nephrogenesis.
本报告描述了一名45岁女性患有组织学表现异常的肾肿瘤。该肿瘤呈白色，与常见的肾细胞癌不同，主要由扁平或立方体细胞在明显水肿的间质内形成的各种形状的小管组成。精心制作的分支或呈乳头状排列的小管伴有局灶性梭形细胞增殖是其特征性表现。免疫组化染色显示波形蛋白和S-100蛋白弥漫性阳性，细胞角蛋白和上皮膜抗原部分阳性，而Leu-M1、Leu-7、CD34及肌肉细胞标志物阴性。肿瘤细胞的超微结构研究显示出腺癌样特征。根据这些组织学、免疫组化和电子显微镜检查结果，建议将该肿瘤定为具有模仿下肾单位肾发生组织学表现的未分类肾细胞癌。
