Nef——一种衔接蛋白的衔接蛋白？
Nef--an adaptor adaptor?
作者信息
Oldridge J, Marsh M
机构信息
Research Council, Laboratory for Molecular Cell Biology, University College, London, UK.
出版信息
Trends Cell Biol. 1998 Aug;8(8):302-5. doi: 10.1016/s0962-8924(98)01318-x.
PMID:9704405
Abstract
The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.
摘要
人类免疫缺陷病毒（HIV）的Nef蛋白是病毒发病机制中的关键因素。这种多功能蛋白的作用之一是降低病毒受体复合物的组成成分CD4以及MHC I类分子在细胞表面的表达。新的研究结果表明，Nef可将CD4与内吞网格蛋白衔接复合物相连，并且可能还会调节内吞途径中的其他步骤。
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