Yu Jinghua, Liu Chunyu, Qu Xinglong, Gao Xinglin, Liu Yue
Department of Echocardiography, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Infectious Diseases and Pathogen Biology Center, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Front Cell Infect Microbiol. 2025 Jan 20;14:1516806. doi: 10.3389/fcimb.2024.1516806. eCollection 2024.
SERINC5 (serine incorporator 5), a member of the serine incorporator family, has been identified as a retrovirus restriction factor that inhibits the fusion of virions with the plasma membrane, thus blocking the release of the viral core into target cells and subsequently attenuating viral infectivity. Several viruses, such as human immunodeficiency virus (HIV), murine leukemia virus (MLV), and equine infectious anemia virus (EIAV), have evolved mechanisms to antagonize the host protein SERINC5 through HIV Nef, MLV glycosylated Gag, and the EIAV S2 protein. These viral proteins degrade SERINC5 on the cell surface through the endolysosomal system. In addition to its direct antiviral ability, SERINC5 also modulates immunity to inhibit the replication of retroviruses and nonretroviruses. This review summarizes the interaction between SERINC5 and viral replication, providing a promising avenue for fighting viral diseases.
丝氨酸整合蛋白5（SERINC5）是丝氨酸整合蛋白家族的一员，已被确定为一种逆转录病毒限制因子，它可抑制病毒粒子与质膜的融合，从而阻止病毒核心释放到靶细胞中，进而减弱病毒的感染性。几种病毒，如人类免疫缺陷病毒（HIV）、鼠白血病病毒（MLV）和马传染性贫血病毒（EIAV），已经进化出通过HIV Nef、MLV糖基化Gag和EIAV S2蛋白来拮抗宿主蛋白SERINC5的机制。这些病毒蛋白通过内溶酶体系统在细胞表面降解SERINC5。除了其直接的抗病毒能力外，SERINC5还调节免疫以抑制逆转录病毒和非逆转录病毒的复制。本综述总结了SERINC5与病毒复制之间的相互作用，为对抗病毒性疾病提供了一条有前景的途径。
