Fowler D H, Gress R E
National Cancer Institute, Department of Experimental Transplantation and Immunology, Bethesda, MD 20892, USA.
Vox Sang. 1998;74 Suppl 2:331-40. doi: 10.1111/j.1423-0410.1998.tb05439.x.
Donor T cells mediate both beneficial and detrimental immune reactions in the setting of allogeneic BMT (alloBMT). T cells mediate the GVL effect and prevent marrow rejection, but also induce GVHD. In an attempt to favorably influence the balance of these allogeneic responses, we have evaluated the effect of donor CD4+, Th1/Th2 and CD8+, Tc1/Tc2 functional T cell subsets in murine marrow transplantation models. Our studies have identified the CD8+ Tc2 population (which is a cytolytic effector secreting the type II cytokines IL-4, IL-5, and IL-10) as a subset capable of mediating the GVL effect and preventing marrow rejection with reduced GVHD. We have also shown that the Tc2 subset can be generated in humans. These studies indicate that administration of donor CD8+ T cells of Tc2 phenotype represents a strategy for improving allo BMT outcome.
在异基因骨髓移植（alloBMT）中，供体T细胞介导有益和有害的免疫反应。T细胞介导移植物抗白血病（GVL）效应并防止骨髓排斥，但也会诱发移植物抗宿主病（GVHD）。为了有利地影响这些异基因反应的平衡，我们在小鼠骨髓移植模型中评估了供体CD4⁺、Th1/Th2和CD8⁺、Tc1/Tc2功能性T细胞亚群的作用。我们的研究已确定CD8⁺Tc2群体（即分泌II型细胞因子白细胞介素-4、白细胞介素-5和白细胞介素-10的溶细胞效应细胞）是一个能够介导GVL效应并防止骨髓排斥且减轻GVHD的亚群。我们还表明，Tc2亚群可以在人类中产生。这些研究表明，给予Tc2表型的供体CD8⁺T细胞是改善异基因骨髓移植结果的一种策略。
