Levkutová M, Revajová V, Levkut M, Leng L
Department of Pathological Anatomy, University of Veterinary Medicine, Kosice, Slovak Republic.
Acta Vet Hung. 1998;46(1):13-8.
Subpopulations of blood lymphocytes (CD2, CD4, CD8, WC1 and IgM-mu chain) were evaluated in clinically manifested bovine papillomatosis. Significantly lower numbers of CD2 (44.7%), CD4 (22.8%) and a lower ratio of CD4/CD8 (1.5) were found in animals with tumours compared to a group of cattle free of papillomas (62.3%, 34%, and 2.3, respectively). On the other hand, significantly higher numbers of gamma/delta+ T lymphocytes (9.6%) and of lymphocytes expressing IgM molecules (35%) were observed in the group of tumour-bearing cattle than in the papilloma-free group (4.8% and 22.1%, respectively). The animals came from a region characterised by elevated concentrations of copper, zinc, arsenic, cadmium and lead in the soil and in the organs of animals. It is supposed that environmental factors predisposed the animals to the development of papillomas.
对临床表现为牛乳头瘤病的牛血液淋巴细胞亚群（CD2、CD4、CD8、WC1和IgM-μ链）进行了评估。与一组无乳头瘤的牛相比（分别为62.3%、34%和2.3），患肿瘤的动物中CD2数量显著降低（44.7%）、CD4数量显著降低（22.8%）且CD4/CD8比值降低（1.5）。另一方面，与无乳头瘤组相比（分别为4.8%和22.1%），在患肿瘤的牛群中观察到γ/δ+T淋巴细胞数量显著增加（9.6%）以及表达IgM分子的淋巴细胞数量显著增加（35%）。这些动物来自一个土壤和动物器官中铜、锌、砷、镉和铅浓度升高的地区。据推测，环境因素使这些动物易患乳头瘤。
