Amos S, Okwuasaba F K, Gamaniel K, Akah P, Wambebe C
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
J Ethnopharmacol. 1998 Jul;61(3):209-13. doi: 10.1016/s0378-8741(98)00046-4.
The effects of the aqueous extract of Pavetta crassipes leaves were studied on gastrointestinal and uterine smooth muscle preparations isolated from rabbit jejunum, guinea pig ileum and rat uterus. The extract produced a concentration-dependent inhibition of the spontaneous motility or elevated tone in these preparations. The inhibitory effects of the extract were not affected by pretreatment with propranolol or yohimbine, but were completely blocked by verapamil pretreatment. The results indicate the presence of biologically active substances whose action might be mediated through calcium channels. A preliminary phytochemical screening of the leaf extract of P. crassipes revealed the presence of flavonoids, tannins and anthraquinones as possible candidates for such inhibitory substances.
研究了厚叶巴夫木树叶水提取物对从兔空肠、豚鼠回肠和大鼠子宫分离出的胃肠道和子宫平滑肌制剂的影响。该提取物对这些制剂的自发运动或升高的张力产生浓度依赖性抑制作用。提取物的抑制作用不受普萘洛尔或育亨宾预处理的影响，但维拉帕米预处理可完全阻断该作用。结果表明存在生物活性物质，其作用可能通过钙通道介导。对厚叶巴夫木树叶提取物进行的初步植物化学筛选显示，黄酮类化合物、单宁和蒽醌可能是这类抑制性物质的候选成分。
