奥利弗丹尼豆（豆科）和埃及无花果（桑科）叶片提取物的止泻活性
Anti-diarrheal activity of the leaf extracts of Daniellia oliveri Hutch and Dalz (Fabaceae) and Ficus sycomorus Miq (Moraceae).
作者信息
Ahmadu A A, Zezi A U, Yaro A H
机构信息
Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria-Nigeria.
出版信息
Afr J Tradit Complement Altern Med. 2007 Jun 10;4(4):524-8.
Abstract
The leaves of the plants Daniellia oliveri (Fabaceae) and Ficus sycomorus (Moraceae) used in diarrhea treatment in Hausa ethnomedicine of Northern Nigeria were investigated. The study was carried out on perfused isolated rabbit jejunum and castor oil-induced diarrhea in mice. The n-butanol extracts: NBD and NBF (0.16-3.2 mg/ml) caused a dose-dependent relaxation of isolated rabbit jejunum. The acute toxicity test for NBD and NBT in mice established an i.p LD(50) of > 4000 mg/kg for D. oliveri and 1131.4 mg/kg for F. sycomorus. In castor oil-induced diarrhea, 80% protection was observed for D. oliveri at doses of 200 mg/kg and 60% protection was observed at 100 mg/kg and 50 mg/kg respectively. For F. sycomorus 100% protection was observed at doses of 120 mg/kg and 60 mg/kg, for the n-butanol extract. The antidiarrheal activity was comparable to loperamide 5 mg/kg. The result revealed that the extracts have pharmacological activity against diarrhea.
摘要
对尼日利亚北部豪萨族民族医学中用于治疗腹泻的植物奥利弗丹尼豆（豆科）和埃及无花果（桑科）的叶子进行了研究。该研究在离体灌注兔空肠和蓖麻油诱导的小鼠腹泻模型上进行。正丁醇提取物：NBD和NBF（0.16 - 3.2毫克/毫升）对离体兔空肠产生剂量依赖性舒张作用。NBD和NBT对小鼠的急性毒性试验确定，奥利弗丹尼豆的腹腔注射半数致死量（LD50）> 4000毫克/千克，埃及无花果为1131.4毫克/千克。在蓖麻油诱导的腹泻模型中，奥利弗丹尼豆在200毫克/千克剂量下观察到8成保护率，在100毫克/千克和50毫克/千克剂量下分别观察到6成保护率。对于埃及无花果，正丁醇提取物在120毫克/千克和60毫克/千克剂量下观察到100%的保护率。止泻活性与5毫克/千克的洛哌丁胺相当。结果表明，这些提取物具有抗腹泻的药理活性。
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