Obasohan A O, Osuji C O, Oforofuo I A
Department of Medicine, Uniben/UBTH, Benin City, Nigeria.
J Hum Hypertens. 1998 Jun;12(6):373-7. doi: 10.1038/sj.jhh.1000597.
To assess sodium-lithium countertransport (SLC) activity and erythrocyte sodium (ENa) levels in black (Nigerian) hypertensive (HT) patients, normotensive (NT) offspring of hypertensive parents and normotensive offspring of normotensive parents, and to determine if increased SLC activity is related to a familial predisposition to hypertension in black subjects as in Caucasians.
The study was done using 60 Nigerian subjects of Edo ethnic origin in three groups of 20 each: (a) untreated new HT patients at the University Teaching Hospital, Benin City; (b) NT children of hypertensive parents (NTHT) traced home and matched for age, sex and body mass index (BMI) with (c) NT children of NT parents (NTNT). SLC activity was measured using a modified method of Canessa et al 1980 and ENa assessed by flame photometry.
SLC was markedly higher in both HT patients and NTHT subjects than the NTNT subjects. The values were 0.351+/-0.011 vs 0.199+/-0.014 mmol Li/rbc (P < 0.0001) and 0.347+/-0.020 vs 0.199+/-0.014 mmol Li/rbc/hr (P < 0.0001), respectively. The values were not different between the HT and the NTHT group (P > 0.05). ENa was higher in the HT group than both NT groups which were similar. Values were 10.55+/-0.46 (HT) vs 7.78+/-0.62 (NTHT) (P < 0.0001) and 10.55+/-0.46 (HT) vs 8.62+/-0.47 mmol/L (P < 0.0001). There were no correlations between either SLC activity or ENa and any of the other measured variables such as age or BMT.
SLC activity was elevated in normotensive children of hypertensive subjects to a similar degree as hypertensive patients and in a pattern reminiscent of that seen in Caucasians. SLC activity may thus be associated with a familial predisposition to hypertension in black subjects as in their Caucasian counterparts.
评估尼日利亚黑人高血压患者、高血压患者的血压正常后代以及血压正常者的血压正常后代的钠-锂逆向转运（SLC）活性和红细胞钠（ENa）水平，并确定SLC活性增加是否如在白种人中那样与黑人高血压家族易感性相关。
本研究使用60名来自江户族的尼日利亚受试者，分为三组，每组20人：（a）贝宁城大学教学医院未经治疗的新诊断高血压患者；（b）追踪到家中的高血压患者的血压正常后代（NTHT），并在年龄、性别和体重指数（BMI）方面与（c）血压正常者的血压正常后代（NTNT）进行匹配。采用Canessa等人1980年改良的方法测量SLC活性，并用火焰光度法评估ENa。
高血压患者和NTHT受试者的SLC均显著高于NTNT受试者。数值分别为0.351±0.011与0.199±0.014 mmol Li/rbc（P<0.0001）以及0.347±0.020与0.199±0.014 mmol Li/rbc/hr（P<0.0001）。高血压组和NTHT组之间的数值无差异（P>0.05）。高血压组的ENa高于两个相似的血压正常组。数值分别为10.55±0.46（高血压组）与7.78±0.62（NTHT组）（P<0.0001）以及10.55±0.46（高血压组）与8.62±0.47 mmol/L（P<0.0001）。SLC活性或ENa与任何其他测量变量如年龄或BMT之间均无相关性。
高血压受试者的血压正常后代的SLC活性升高程度与高血压患者相似，且模式与白种人中所见相似。因此，SLC活性可能如在白种人对应人群中一样，与黑人高血压家族易感性相关。
