Baranovskaya S, Kudinov S, Fomicheva E, Vasina V, Solovieva D, Khavinson V, Schwartz E
Laboratory of Human Molecular Genetics, Petersburg Nuclear Physics Institute, St.Petersburg Area, 188350, Russia.
Mol Genet Metab. 1998 Jun;64(2):155-7. doi: 10.1006/mgme.1998.2697.
A single factor V gene G-A mutation (Arg506Gln) underlying activated protein C (APC) resistance is a common risk factor for venous thromboembolism. It is still unclear whether the factor V Leiden predisposes patients to arterial thrombosis and myocardial infarction (MI). To determine a correlation between the factor V Leiden mutation and MI in different age categories, DNA samples from 287 patients with "early" and "late" MI were investigated. As control groups 373 young subjects (mean age 11 years) and 110 elderly ones (mean age 80 years) were studied. We found a significant difference in mutant allele distribution in the "late" MI group compared to the "early" MI group (chi2 = 9.86, OR = 13,7, P < 0.005) and the control group of elderly subjects (chi2 = 5.92, OR = 8.6, P < 0.02). The mean age of MI patients carrying the Leiden mutation was 72 years, i.e., 12 years higher than the mean age of all investigated MI patients (60 years). Thus, we found a statistically significant correlation between MI and factor V Leiden mutation in elderly subjects.
激活蛋白C（APC）抵抗所涉及的单个因子V基因G-A突变（Arg506Gln）是静脉血栓栓塞的常见危险因素。因子V莱顿突变是否会使患者易患动脉血栓形成和心肌梗死（MI）仍不清楚。为了确定因子V莱顿突变与不同年龄组MI之间的相关性，对287例“早期”和“晚期”MI患者的DNA样本进行了研究。作为对照组，研究了373名年轻受试者（平均年龄11岁）和110名老年受试者（平均年龄80岁）。我们发现，与“早期”MI组（χ2 = 9.86，OR = 13.7，P < 0.005）和老年受试者对照组（χ2 = 5.92，OR = 8.6，P < 0.02）相比，“晚期”MI组的突变等位基因分布存在显著差异。携带莱顿突变的MI患者的平均年龄为72岁，即比所有研究的MI患者的平均年龄（60岁）高12岁。因此，我们发现老年受试者中MI与因子V莱顿突变之间存在统计学上的显著相关性。
