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一种耐多药的耐甲氧西林金黄色葡萄球菌克隆的洲际传播。

Intercontinental spread of a multidrug-resistant methicillin-resistant Staphylococcus aureus clone.

作者信息

Aires de Sousa M, Sanches I S, Ferro M L, Vaz M J, Saraiva Z, Tendeiro T, Serra J, de Lencastre H

机构信息

Unidade de Genética Molecular, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa (ITQB/UNL), Oeiras, Lisbon, Portugal.

出版信息

J Clin Microbiol. 1998 Sep;36(9):2590-6. doi: 10.1128/JCM.36.9.2590-2596.1998.

DOI:10.1128/JCM.36.9.2590-2596.1998
PMID:9705398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105168/
Abstract

Two hundred ten methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered between 1990 and 1997 from three Portuguese hospitals located in Lisbon and Oporto were analyzed by molecular fingerprinting techniques. The hybridization of ClaI restriction digests with the mecA- and Tn554-specific DNA probes combined with pulsed-field gel electrophoresis documented the abrupt appearance and extensive intrahospital spread of the Brazilian epidemic MRSA clone in the 1995 samples of each one of the three hospitals analyzed-suggesting the intercontinental transfer of this strain from Brazil to Portugal. The appearance of this clone may challenge the dominance of another highly epidemic imported clone-the Iberian MRSA, currently the most widely spread MRSA clone in Portuguese hospitals.

摘要

对1990年至1997年间从位于里斯本和波尔图的三家葡萄牙医院分离出的210株耐甲氧西林金黄色葡萄球菌（MRSA）进行了分子指纹技术分析。用mecA和Tn554特异性DNA探针与ClaI限制性酶切片段杂交，并结合脉冲场凝胶电泳，记录了1995年这三家医院所分析的每个样本中巴西流行MRSA克隆的突然出现和在医院内的广泛传播，这表明该菌株从巴西洲际转移到了葡萄牙。这个克隆的出现可能会挑战另一个高度流行的输入性克隆——伊比利亚MRSA的主导地位，目前伊比利亚MRSA是葡萄牙医院中传播最广的MRSA克隆。

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本文引用的文献

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Virtually all methicillin-resistant Staphylococcus aureus (MRSA) infections in the largest Portuguese teaching hospital are caused by two internationally spread multiresistant strains: the 'Iberian' and the 'Brazilian' clones of MRSA.在葡萄牙最大的教学医院，几乎所有耐甲氧西林金黄色葡萄球菌（MRSA）感染都是由两种在国际上传播的多重耐药菌株引起的：MRSA的“Iberian”和“Brazilian”克隆株。
Clin Microbiol Infect. 1998 Jul;4(7):373-384. doi: 10.1111/j.1469-0691.1998.tb00081.x.
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Extensive intra-hospital spread of a methicillin-resistant staphylococcal clone.耐甲氧西林葡萄球菌克隆在医院内的广泛传播。
Int J Infect Dis. 1998 Jul-Sep;3(1):26-31. doi: 10.1016/s1201-9712(98)90091-1.
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Spread of the multiresistant Iberian clone of methicillin-resistant Staphylococcus aureus (MRSA) to Italy and Scotland.耐甲氧西林金黄色葡萄球菌（MRSA）的多重耐药伊比利亚克隆株传播至意大利和苏格兰。
Microb Drug Resist. 1998 Summer;4(2):107-12. doi: 10.1089/mdr.1998.4.107.
4
Spread of the Spanish multi-resistant serotype 23F clone of Streptococcus pneumoniae to Seoul, Korea.西班牙多重耐药性肺炎链球菌23F血清型克隆株传播至韩国首尔。
Microb Drug Resist. 1997 Fall;3(3):253-7. doi: 10.1089/mdr.1997.3.253.
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Multidrug-resistant Iberian epidemic clone of methicillin-resistant Staphylococcus aureus endemic in a hospital in northern Portugal.在葡萄牙北部一家医院中流行的耐多药伊比利亚耐甲氧西林金黄色葡萄球菌克隆株。
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6
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Concordant clonal delineation of methicillin-resistant Staphylococcus aureus by macrorestriction analysis and polymerase chain reaction genome fingerprinting.通过宏观限制性分析和聚合酶链反应基因组指纹图谱对耐甲氧西林金黄色葡萄球菌进行一致的克隆鉴定。
J Clin Microbiol. 1993 Aug;31(8):1964-70. doi: 10.1128/jcm.31.8.1964-1970.1993.