分泌型白细胞蛋白酶抑制剂（SLPI）可将免疫球蛋白E介导的组胺从鼻黏膜中的释放抑制至自发释放水平。
IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
作者信息
Westin U, Lundberg E, Ohlsson K
机构信息
Department of Otolaryngology and Head and Neck Surgery, University Hospital of Malmö, University of Lund, Sweden.
出版信息
Mediators Inflamm. 1998;7(3):217-20. doi: 10.1080/09629359891162.
Abstract
The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.
摘要
分泌型白细胞蛋白酶抑制剂（SLPI）是一种低分子量蛋白酶抑制剂，可抑制诸如弹性蛋白酶和组织蛋白酶G等在吞噬作用期间从白细胞释放的蛋白酶。本研究的目的是确定SLPI是否能够抑制IgE介导的组胺释放。本体外研究使用了11名无特应性体质受试者的鼻黏膜。我们发现SLPI以剂量依赖的方式抑制组胺释放，但对组胺的自发释放没有影响。
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