Moriyama T, Kataoka H, Hamasuna R, Yokogami K, Uehara H, Kawano H, Goya T, Tsubouchi H, Koono M, Wakisaka S
Department of Neurosurgery, Miyazaki Medical College, Japan.
Biochem Biophys Res Commun. 1998 Aug 10;249(1):73-7. doi: 10.1006/bbrc.1998.9078.
Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. We investigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of VEGF proteins accompanying increased transcription of VEGF mRNA in a dose-dependent fashion. Since malignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas.
最近的研究结果表明，肝细胞生长因子/分散因子（HGF/SF）促进人类胶质瘤的恶性进展。我们研究了HGF/SF对c-Met/HGF受体阳性人类胶质瘤细胞系血管内皮生长因子（VEGF）表达的影响。用不同浓度的HGF/SF处理胶质瘤细胞，导致VEGF蛋白分泌增加，同时VEGF mRNA转录呈剂量依赖性增加。由于恶性胶质瘤经常共表达HGF/SF及其受体，这些结果表明，HGF/SF可能通过自分泌诱导恶性胶质瘤中VEGF的表达和分泌，作为一种间接的血管生成因子。
