Coronato S, Laguens G E, Spinelli O M, Salas M A, Di Girolamo W
Càtedra de Patologia B, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina.
Medicina (B Aires). 1998;58(2):209-18.
The aim of this review is to update the knowledge on dendritic cells (CD), as potent antigen-presenting cells (APC) expressing class II major histocompatibility (MHC) antigen. The different types of DC are derived from a common bone marrow precursor. They differentiate and migrate to lymphoid and non-lymphoid tissues under the influence of diverse stimuli. After binding antigen in their periphery they move to the lymph node activating T cells. Depending on the microenvironment, DC express several surface markers and secrete cytokines such as IL-12, Il-1 and TNF alpha. DC play a role in the pathogenesis of autoimmune and viral diseases being relevant in AIDS. These cells also infiltrate human tumors where they could be involved in the induction of anti-tumor immune response. The immunostimulatory properties of DC are currently applied in DC-based therapies of melanoma and lymphoma patients.
本综述的目的是更新关于树突状细胞（DC）的知识，树突状细胞是表达II类主要组织相容性（MHC）抗原的强效抗原呈递细胞（APC）。不同类型的DC源自共同的骨髓前体细胞。它们在多种刺激的影响下分化并迁移至淋巴组织和非淋巴组织。在其外周结合抗原后，它们迁移至淋巴结激活T细胞。根据微环境的不同，DC表达多种表面标志物并分泌细胞因子，如IL-12、IL-1和肿瘤坏死因子α。DC在自身免疫性疾病和病毒性疾病的发病机制中起作用，与艾滋病相关。这些细胞也浸润人类肿瘤，在其中可能参与抗肿瘤免疫反应的诱导。DC的免疫刺激特性目前应用于基于DC的黑色素瘤和淋巴瘤患者治疗。
