Leteurtre E, Boman F, Farine M O, Leroy J L, Gosselin B
Service Anatomie et Cytologie Pathologiques C, Hôpital Calmette, Lille.
Ann Pathol. 1998 Jul;18(3):172-7.
The morphological criteria for the diagnosis of endocervical atypia and dysplasia are variably defined. Diagnosis is difficult. MIB-1 (Ki-67) cell proliferation-associated antigen was detected retrospectively by immunohistochemistry in 230 cervical cone specimens. The percentage of MIB-1 positive cells was 1 to 25% (median 2%) and limited to small hot spots in normal and subnormal glands (140 cases). It was 1 to 30% (median 4%) in endometrioid metaplasia and microglandular hyperplasia (55 cases); 30 to 60 (median 40%) and limited to 1-3 glands in atypia (24 cases); 45 to 60% (median 50%) and diffusely distributed in dysplasia (5 cases). In situ (3 cases) and invasive (3 cases) adenocarcinomas were characterized by a high% (> 60) of MIB-1 positive cells.
宫颈管异型增生和发育异常的诊断形态学标准定义不一。诊断困难。通过免疫组织化学对230例宫颈锥切标本进行回顾性检测，以检测MIB-1（Ki-67）细胞增殖相关抗原。MIB-1阳性细胞百分比在正常和亚正常腺体中为1%至25%（中位数为2%），且局限于小的热点区域（140例）。在子宫内膜样化生和微小腺体增生中为1%至30%（中位数为4%）（55例）；在异型增生中为30%至60%（中位数为40%），且局限于1至3个腺体（24例）；在发育异常中为45%至60%（中位数为50%），且呈弥漫性分布（5例）。原位腺癌（3例）和浸润性腺癌（3例）的特征是MIB-1阳性细胞百分比高（>60%）。
