催乳素调节伴有催乳素瘤的系统性红斑狼疮的疾病活动。

Prolactin modulates the disease activity of systemic lupus erythematosus accompanied by prolactinoma.

作者信息

Funauchi M, Ikoma S, Enomoto H, Sugiyama M, Ohno M, Hamada K, Kanamaru A

机构信息

Third Department of Internal Medicine, Kinki University School of Medicine, Japan.

出版信息

Clin Exp Rheumatol. 1998 Jul-Aug;16(4):479-82.

PMID:9706433

Abstract

We present a 31-year-old female patient with systemic lupus erythematosus (SLE) which was accompanied by prolactinoma. Her SLE flared when the plasma levels of prolactin (PRL) increased, and subsided when these levels decreased following the administration of bromocriptine, irrespective of the glucocorticoid dosage. For the 29 plasma samples obtained during the clinical course, PRL levels were significantly correlated to the serum anti-DNA antibody titers (r = 0.55, p < 0.05) and inversely to the serum complement activity (r = -0.33, p < 0.05). This result suggests that PRL may play a role in the pathogenesis of SLE in some patients.

摘要

我们报告一例31岁患有系统性红斑狼疮（SLE）并伴有催乳素瘤的女性患者。当催乳素（PRL）血浆水平升高时，她的SLE病情加重，而在服用溴隐亭后PRL水平下降时病情缓解，且与糖皮质激素剂量无关。在临床病程中采集的29份血浆样本中，PRL水平与血清抗DNA抗体滴度显著相关（r = 0.55，p < 0.05），与血清补体活性呈负相关（r = -0.33，p < 0.05）。这一结果表明PRL可能在部分患者SLE的发病机制中起作用。