Hioki M, Iedokoro Y, Yamagishi S, Yamashita Y, Orii K, Hirano S, Hirata T, Masuda S, Kutukata N, Hisayoshi T, Tanaka S
Second Department of Surgery, Nippon Medical School, Tokyo, Japan.
Int Surg. 1998 Jan-Mar;83(1):11-4.
Pericardial adhesions pose a major problem during re-operative cardiac surgical procedures. The purpose of this study was to determine the effect of Batroxobin, a fibrinogen depleting agent, on the incidence of experimental pericardial adhesions. Twenty-four rabbits were divided into 3 groups of 8 rabbits each and pericardial mesothelial injury was induced by abrasion. Group A included rabbits receiving no further treatment, Group B included rabbits receiving intrapericardial injection of Ringer's solution, and Group C included rabbits receiving intrapericardial injection of Batroxobin. Three weeks after surgery, the incidence of adhesions in Groups B and C was compared with that in Group A. Pericardial adhesions found in 80% of the rabbits in Groups A and B. However, only 14% of the rabbits in Group C had pericardial adhesions (p < 0.05). Our findings demonstrated that intrapericardial Batroxobin reduced the incidence of pericardial adhesions in an animal model.
心包粘连在心脏再次手术过程中是一个主要问题。本研究的目的是确定巴曲酶（一种消耗纤维蛋白原的药物）对实验性心包粘连发生率的影响。将24只兔子分为3组，每组8只，通过磨损诱导心包间皮损伤。A组包括未接受进一步治疗的兔子，B组包括接受心包内注射林格液的兔子，C组包括接受心包内注射巴曲酶的兔子。术后三周，将B组和C组的粘连发生率与A组进行比较。A组和B组80%的兔子发现有心包粘连。然而，C组只有14%的兔子有心包粘连（p<0.05）。我们的研究结果表明，心包内注射巴曲酶可降低动物模型的心包粘连发生率。
