Lam K Y, Lo C Y
Department of Pathology and Surgery, Queen Mary Hospital, Hong Kong.
Am J Gastroenterol. 1998 Aug;93(8):1232-5. doi: 10.1111/j.1572-0241.1998.401_w.x.
The molecular genetic of pancreatic endocrine tumor (PET) has rarely been studied in depth because of its rarity. The aim of this study is to determine if there is any implication of p53 overexpression on the pathogenesis and clinicopathological parameters of PET.
This study examines the immunohistochemical expression of the p53 gene product in 52 PETs (32 insulinomas, three gastrinomas, two glucagonomas, one carcinoid, and 14 nonfunctional tumors) from Chinese patients (27 men, 25 women) collected over a 23-yr period. Of these, 21% were malignant.
Irrespective of their demographic data, clinical behavior, hormonal status, or pathological features, none of the 52 PETs showed p53 overexpression.
This observation, together with an analysis of the literature, suggests that p53 gene aberrations may not be important in the pathogenesis of PET.
胰腺内分泌肿瘤（PET）较为罕见，因此对其分子遗传学的深入研究较少。本研究的目的是确定p53过表达是否对PET的发病机制及临床病理参数有影响。
本研究检测了52例PET患者（27例男性，25例女性）中p53基因产物的免疫组化表达情况。这些患者的肿瘤样本是在23年期间收集的，包括32例胰岛素瘤、3例胃泌素瘤、2例胰高血糖素瘤、1例类癌和14例无功能性肿瘤，其中21%为恶性肿瘤。
无论患者的人口统计学数据、临床行为、激素状态或病理特征如何，52例PET中均未显示p53过表达。
这一观察结果，结合文献分析表明，p53基因异常在PET的发病机制中可能并不重要。
