Lustig L R, Lee K C, Murr A, Deschler D, Kingdom T
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco 94143-0342, USA.
Laryngoscope. 1998 Aug;108(8 Pt 1):1199-205. doi: 10.1097/00005537-199808000-00019.
Benign lymphoepithelial cysts (BLCs) are a widely recognized cause of parotid gland swelling in HIV-infected patients. Although they are neither invasive nor associated with malignant degeneration, BLCs can become large and disfiguring. Multiple modalities have been used to control these cysts, but no ideal treatment has been identified. The current study examines the efficacy of doxycycline as a BLC sclerosant in eight patients, and nine BLCs (bilateral BLC in one patient). Follow-up ranged from 12 to 17 months in all cases. Doxycycline sclerosis controlled further cyst growth in 100% of cases with no serious complications. The BLCs became negligible or unnoticeable in two patients, and in six patients (seven BLCs) the cyst became fibrosed and showed no evidence of further growth over the follow-up period. Although further studies are needed to determine the long-term efficacy of this treatment modality, doxycycline sclerosis appears to offer a simple, safe, cost-effective, office-based therapeutic option for the treatment of BLCs in patients infected with HIV.
良性淋巴上皮囊肿（BLCs）是HIV感染患者腮腺肿大的一个广为人知的原因。尽管它们既不具有侵袭性，也不与恶性变相关，但BLCs可能会变大并导致面容毁损。已经使用了多种方法来控制这些囊肿，但尚未确定理想的治疗方法。当前研究检测了强力霉素作为BLC硬化剂对8例患者和9个BLCs（1例患者为双侧BLC）的疗效。所有病例的随访时间为12至17个月。强力霉素硬化术在100%的病例中控制了囊肿的进一步生长，且无严重并发症。2例患者的BLCs变得微不足道或难以察觉，6例患者（7个BLCs）的囊肿发生纤维化，在随访期间未显示进一步生长的迹象。尽管需要进一步研究来确定这种治疗方式的长期疗效，但强力霉素硬化术似乎为感染HIV的患者治疗BLCs提供了一种简单、安全、经济有效且基于门诊的治疗选择。
