银屑病治疗对银屑病患者肝微粒体酶活性的影响。
Effects of antipsoriatic therapies on hepatic microsomal enzyme activity in patients with psoriasis.
作者信息
Brockmeyer N H, Frühauf S, Mertins L, Barthel B, Goos M
机构信息
Department of Dermatology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, D-44791 Bochum, Germany.
出版信息
Eur J Med Res. 1998 Aug 18;3(8):361-6.
OBJECTIVE
The influence of several antipsoriatic therapies on microsomal enzyme activity was assessed by comparing measurements of antipyrine kinetics prior to and two weeks after initiation of therapy.
METHODS
Serum and urine analysis was carried out by means of high performance liquid chromatography (HPLC). Each form of therapy was examined separately. 10 patients were treated with etretinate. The groups treated with 8-methoxypsoralene (8-MOP) in combination with UVA irradiation (PUVA), etretinate in combination with PUVA (RePUVA), anthralin, or combined UVA and UVB irradiation (SUP) consisted of 7 patients each.
RESULTS
Neither anthralin nor SUP therapy led to any significant changes in antipyrine kinetics. Antipyrine clearance under the other regimens was, however, reduced. It was 23% lower in PUVA-treated patients, 20% lower in those receiving retinoids and 28% lower in those under RePUVA (p<0.05 - 0. 01).
CONCLUSIONS
PUVA, etretinate and RePUVA inhibit microsomal enzyme activity in the liver. Possible drug interactions with other P subset450 inducing or inhibiting agents should be considered in the therapy of psoriatic patients.
目的
通过比较治疗开始前及开始两周后安替比林动力学测量值，评估几种银屑病治疗方法对微粒体酶活性的影响。
方法
采用高效液相色谱法（HPLC）进行血清和尿液分析。每种治疗方法分别进行检查。10例患者接受依曲替酯治疗。接受8-甲氧基补骨脂素（8-MOP）联合长波紫外线照射（PUVA）、依曲替酯联合PUVA（RePUVA）、蒽林或联合长波紫外线和中波紫外线照射（SUP）治疗的组每组各有7例患者。
结果
蒽林和SUP治疗均未导致安替比林动力学发生任何显著变化。然而，其他治疗方案下的安替比林清除率降低。接受PUVA治疗的患者降低了23%，接受维甲酸治疗的患者降低了20%，接受RePUVA治疗的患者降低了28%（p<0.05 - 0.01）。
结论
PUVA、依曲替酯和RePUVA抑制肝脏微粒体酶活性。在银屑病患者的治疗中应考虑与其他细胞色素P450诱导剂或抑制剂可能存在的药物相互作用。
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