van de Wal Y, Kooy Y M, van Veelen P A, Peña S A, Mearin L M, Molberg O, Lundin K E, Sollid L M, Mutis T, Benckhuijsen W E, Drijfhout J W, Koning F
Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10050-4. doi: 10.1073/pnas.95.17.10050.
Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat gluten and related proteins. The large majority of patients expresses the HLA-DQ2 and/or DQ8 molecules, and gluten-specific HLA-DQ-restricted T cells have been found at the site of the lesion in the gut. The nature of peptides that are recognized by such T cells, however, has been unclear so far. We now report the identification of a gliadin-derived epitope that dominantly is recognized by intestinal gluten-specific HLA-DQ8-restricted T cells. The characterization of such epitopes is a key step toward the development of strategies to interfere in mechanisms involved in the pathogenesis of celiac disease.
乳糜泻是一种常见的严重肠道疾病，由对膳食中的小麦麸质及相关蛋白质不耐受所致。绝大多数患者表达HLA-DQ2和/或DQ8分子，并且在肠道病变部位发现了麸质特异性的HLA-DQ限制性T细胞。然而，这类T细胞所识别的肽的性质迄今尚不清楚。我们现在报告鉴定出一种麦醇溶蛋白衍生的表位，它主要被肠道麸质特异性HLA-DQ8限制性T细胞所识别。此类表位的特性鉴定是开发干预乳糜泻发病机制策略的关键一步。
