Sollid L M, Thorsby E
Institute of Transplantation Immunology, University of Oslo, National Hospital, Norway.
Gastroenterology. 1993 Sep;105(3):910-22. doi: 10.1016/0016-5085(93)90912-v.
The overrepresentation of particular HLA alleles in patients with celiac disease was first noted two decades ago. Several lines of evidence obtained during the last years strongly suggest that a particular HLA-DQ heterodimer, encoded by the DQA10501 and DQB10201 genes in cis or trans configuration, confers the primary disease susceptibility. This paper reviews the evidence behind this concept and discusses how this particular DQ molecule may be involved in the pathogenesis.
二十年前首次注意到乳糜泻患者中特定HLA等位基因的过度表达。过去几年获得的几条证据有力地表明，由DQA10501和DQB10201基因以顺式或反式构型编码的特定HLA-DQ异二聚体赋予了主要的疾病易感性。本文回顾了这一概念背后的证据，并讨论了这种特定的DQ分子可能如何参与发病机制。
