Petta S, Bilotta L, Pacchiele R, Palleschi G, Aloisi P
Dipartimento di Urologia U. Bracci, Università La Sapienza, Roma.
Arch Ital Urol Androl. 1998 Jun;70(3 Suppl):55-8.
We evaluated the long term incidence of lower urinary tract neoplasms in patients with primary transitional bladder carcinoma. 8 patients had lower urinary tract neoplasm after a median elapse of time of 44 months (range 28 to 70). In 5 patients wa present vesicoureteral reflux. All the patients were undergone trial of BCG after the first recurrence of bladder carcinoma. We suppose that the vesicoureteral reflux may be the possible cause of ureteral neoplasm onset. Because of patients with primary bladder tumors are at the risk for lower urinary tract neoplasm, we suggest the need regular and continuous monitoring in case of frequent recurrence of transitional cell carcinoma of the bladder.
我们评估了原发性移行性膀胱癌患者下尿路肿瘤的长期发病率。8例患者在中位时间44个月（范围28至70个月）后发生下尿路肿瘤。5例患者存在膀胱输尿管反流。所有患者在膀胱癌首次复发后均接受了卡介苗治疗。我们推测膀胱输尿管反流可能是输尿管肿瘤发病的可能原因。由于原发性膀胱肿瘤患者有发生下尿路肿瘤的风险，我们建议对于膀胱移行细胞癌频繁复发的情况需要进行定期持续监测。
