Kusumakumary P, Ajithkumar T V, Ratheesan K, Chellam V G, Nair M K
Division of Pediatric Oncology and Radiation Oncology, Regional Cencer Center, Trivandrum, Kerala.
Indian Pediatr. 1998 Mar;35(3):223-9.
To determine the clinical pattern and outcome of children with neuroblastoma.
Retrospective analysis.
Hospital based information from the case sheets.
91 children with age upto 14 years treated in the Regional Cancer Center, Trivandrum.
Clinical presentation, metastatic pattern and treatment outcome were analyzed.
Median age of the study group was 2.5 years with a male:female ratio of 1.6:1. Fifteen per cent children had early stage disease and 85% advanced disease. Five children with stage III and 22 with stage IV disease did not receive may active treatment. The remaining 64 children were evaluated for this analysis with a survival rate of 25%. Two of the four (50%) stage I, four of the six (83.3%) stage II, five of the 18 (27.7%) stage III, three of the 32 (9%) stage IV and two of the four (50%) stage IVs patients are long term survivors.
Majority of the children (> 80%) presented with advanced disease and outcome remained poor. Only 27% of stage III and 9% of stage IV patients are long term survivors in our series. In future, approaches to detect disease at an early stage and aggressive therapeutic strategies in selected patients may improve survival.
确定神经母细胞瘤患儿的临床特征及预后。
回顾性分析。
基于医院病历的信息。
91名年龄在14岁以下、在特里凡得琅地区癌症中心接受治疗的儿童。
分析临床表现、转移模式及治疗结果。
研究组的中位年龄为2.5岁，男女比例为1.6:1。15%的患儿为早期疾病，85%为晚期疾病。5名III期和22名IV期疾病患儿未接受积极治疗。其余64名患儿纳入本分析，生存率为25%。4名I期患儿中有2名（50%）、6名II期患儿中有4名（83.3%）、18名III期患儿中有5名（27.7%）、32名IV期患儿中有3名（9%）以及4名IVs期患儿中有2名（50%）为长期存活者。
大多数患儿（>80%）表现为晚期疾病，预后仍然较差。在我们的研究系列中，只有27%的III期和9%的IV期患儿为长期存活者。未来，早期发现疾病的方法以及针对特定患者的积极治疗策略可能会提高生存率。
