Kernbaum S, Debranbander C, Bouton C, Nandrup C E, Trinh Dinh H, Bastin R
Ann Med Interne (Paris). 1976 Jun-Jul;127(6-7):429-36.
One case is presented whose characteristics features were breast hypertrophy, normal immune functions and the efficacy of cyclophosphamide alone : A complete remission is present 31 months after the granuloma started, after 7 and a half months of treatment by cyclophosphamide, 14 months after its interruption by the patient. It is proposed that lethal midline granuloma is a localised form of Wegener's granulomatosis ; between these extreme forms are the limited (pulomonary) form of Wegener's granulomatosis, and the lethal midline granuloma with cutaneous, glandular, digestive or urethrogenital involvements. Therapeutic is briefly reviewed and the efficacy of cyclophosphamide claimed.
乳腺肥大、免疫功能正常且单独使用环磷酰胺有效。肉芽肿出现31个月后，在患者接受环磷酰胺治疗7个半月、停药14个月后实现完全缓解。有人提出致死性中线肉芽肿是韦格纳肉芽肿的一种局限性形式；在这些极端形式之间的是韦格纳肉芽肿的局限性（肺部）形式，以及伴有皮肤、腺体、消化道或泌尿生殖系统受累的致死性中线肉芽肿。本文简要回顾了治疗方法并声称环磷酰胺有效。
