Turkoski B B
Kent State University, Ohio, USA.
Geriatr Nurs. 1998 May-Jun;19(3):146-51. doi: 10.1016/s0197-4572(98)90060-x.
The concept of chronopharmacology has significant implications for drug delivery systems. Age and illness put the elderly at greater risk for adverse drug effects, and nurses caring for the elderly have a challenging opportunity to measurably improve the quality of their care by applying chronotherapeutic concepts. Pharmacologic chronotherapy is a developing science that holds much hope for increasing the effectiveness of drug therapy and for reducing the incidence of toxic drug reactions. Nurses who are aware of the principles on which chronotherapy is based are in a unique position to improve the effectiveness of pharmacotherapy for all clients. However, appropriate timing of medications is especially important among elderly clients whose physiological processes are altered or changed by age and chronic illness. In this article, the basis of chronotherapy is discussed, and several therapeutic applications are identified.
时辰药理学的概念对药物递送系统具有重要意义。年龄和疾病使老年人面临更大的药物不良反应风险，而照顾老年人的护士有一个具有挑战性的机会，通过应用时辰治疗学概念来显著提高他们的护理质量。药物时辰治疗学是一门不断发展的科学，在提高药物治疗效果和降低药物毒性反应发生率方面充满希望。了解时辰治疗学所基于的原则的护士，处于一个独特的位置，能够提高所有患者药物治疗的有效性。然而，对于生理过程因年龄和慢性病而改变或变化的老年患者，药物的适当给药时间尤为重要。在本文中，将讨论时辰治疗学的基础，并确定几种治疗应用。
