Fujimura Akio, Ushijima Kentaro
Department of Clinical Pharmacology, Jichi Medical University, Tochigi, Japan.
Division of Pharmaceutics, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Yamaguchi, Japan.
Expert Rev Clin Pharmacol. 2023 Jul-Dec;16(7):655-668. doi: 10.1080/17512433.2023.2233438. Epub 2023 Jul 7.
Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a number of drugs and affects their therapeutic efficacy and toxicity depending on the time of day they are administered. Chronopharmacology is a method for incorporating knowledge about circadian rhythm into pharmacotherapy. Chronotherapy, which is the clinical application of chronopharmacology, is particularly relevant when the risk and/or severity of symptoms of a disease change in a predictable manner over time. Chronotherapy has potential benefits in the treatment of many diseases.
Although a considerable amount of knowledge about chronopharmacology and chronotherapy has been accumulated, its therapeutic application in clinical practice remains limited in terms of therapy optimization. Resolution of these issues will improve our ability to deliver adequate drug treatment.
We propose four approaches for promoting chronotherapy-based drug treatment in clinical practice: targeting drug development and regulatory authorities; education about chronotherapy; drug information for both health professionals and consumers; and a chronotherapy network.
昼夜节律影响多种药物的药代动力学和药效学，并根据给药时间影响其治疗效果和毒性。时辰药理学是一种将昼夜节律知识纳入药物治疗的方法。时辰疗法作为时辰药理学的临床应用，当疾病症状的风险和/或严重程度随时间以可预测的方式变化时尤为相关。时辰疗法在许多疾病的治疗中具有潜在益处。
尽管已经积累了大量关于时辰药理学和时辰疗法的知识，但其在临床实践中的治疗应用在优化治疗方面仍然有限。解决这些问题将提高我们提供充分药物治疗的能力。
我们提出了四种在临床实践中促进基于时辰疗法的药物治疗的方法：针对药物研发和监管机构；开展时辰疗法教育；为卫生专业人员和消费者提供药物信息；以及建立一个时辰疗法网络。
