Heinze E, Beischer W, Teller W M
Eur J Pediatr. 1978 May 22;128(1):41-8. doi: 10.1007/BF00496925.
The effect of glucose on insulin release and the influence of glibenclamide on linear growth were determined in five growth hormone (STH) deficient children who were treated with human growth hormone. It was found that the administration of 5 I.U. of human growth hormone twice a week improved the defective insulin secretion while prolongation of the week improved the defective insulin secretion while prolongation of the interval between growth hormone injections to 7 days had no effect on beta-cell function. The addition of treatment with 5 mg/day glibenclamide to the regular human growth hormone injections resulted in an increased growth rate in four children while one patient developed hypoglycemic symptoms. The results show that STH-deficient children may benefit from combined treatment with human growth hormone plus glibenclamide.
在五名接受人生长激素治疗的生长激素（STH）缺乏儿童中，测定了葡萄糖对胰岛素释放的影响以及格列本脲对线性生长的影响。发现每周两次注射5国际单位人生长激素可改善胰岛素分泌缺陷，而将生长激素注射间隔延长至7天对β细胞功能无影响。在常规人生长激素注射基础上加用5毫克/天格列本脲治疗，四名儿童生长速率增加，一名患者出现低血糖症状。结果表明，生长激素缺乏儿童可能从人生长激素加格列本脲联合治疗中获益。
