Synthesis and biological activity of bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate.
作者信息
Kang S H, Sinhababu A K, Cho M J
机构信息
School of Pharmacy, University of North Carolina, Chapel Hill 27514, USA.
出版信息
Nucleosides Nucleotides. 1998 Jun;17(6):1089-98. doi: 10.1080/07328319808004222.
PMID:9708324
Abstract
Bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate was prepared as a prodrug to generate 2'-azido-2'-deoxyuridine 5'-diphosphate inside the cell. A synthetic route utilizing stannyl phosphate was adopted in the preparation. The prodrug was evaluated for cell growth inhibition against a variety of tumor cell lines along with 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine.
摘要
Zotero 插件