• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1,2,4,6-噻三嗪-3-酮1,1-二氧化物核苷的合成及其抗HIV特性

Synthesis and anti-HIV properties of 1,2,4,6-thiatriazin-3-one 1,1-dioxide nucleosides.

作者信息

Ochoa C, Provencio R, Jimeno M L, Balzarini J, De Clercq E

机构信息

Instituto de Química Médica (CSIC), Juan de la Cierva, Madrid, Spain.

出版信息

Nucleosides Nucleotides. 1998 May;17(5):901-10. doi: 10.1080/07328319808003462.

DOI:10.1080/07328319808003462
PMID:9708331
Abstract

Synthesis of 1,2,4,6-thiatriazine 1,1-dioxide nucleosides is now reported for the first time. In order to know the conformation of the nucleosides, a NMR study has been carried out. Anti-HIV-1 and HIV-2 properties of the nucleosides have been tested. These compounds have not shown activity at subtoxic concentrations.

摘要

首次报道了1,2,4,6-硫代三嗪1,1-二氧化物核苷的合成。为了了解核苷的构象，已进行了核磁共振研究。对核苷的抗HIV-1和HIV-2特性进行了测试。这些化合物在亚毒性浓度下未显示出活性。

相似文献

1
Synthesis and anti-HIV properties of 1,2,4,6-thiatriazin-3-one 1,1-dioxide nucleosides.1,2,4,6-噻三嗪-3-酮1,1-二氧化物核苷的合成及其抗HIV特性
Nucleosides Nucleotides. 1998 May;17(5):901-10. doi: 10.1080/07328319808003462.
2
Synthesis and anti-HIV activity of different novel nonclassical nucleosides.不同新型非经典核苷的合成及其抗HIV活性
Nucleosides Nucleotides. 1999 Jan;18(1):113-23. doi: 10.1080/07328319908045598.
3
New acyclonucleosides: synthesis and anti-HIV activity.新型无环核苷：合成与抗HIV活性。
Nucleosides Nucleotides Nucleic Acids. 2005;24(8):1249-63. doi: 10.1081/NCN-200067423.
4
Synthesis of a nucleoside bioconjugate system as a potential anti-HIV agent.
Nucleosides Nucleotides. 1999 Apr-May;18(4-5):737-8. doi: 10.1080/15257779908041559.
5
Synthesis and anti-HIV activity of novel phenyl branched cyclopropyl nucleosides.新型苯基支链环丙基核苷的合成及其抗HIV活性
Farmaco. 2005 Sep;60(9):739-44. doi: 10.1016/j.farmac.2005.06.011.
6
Synthesis of oxathiolane imidazole nucleosides.
Farmaco. 2002 Dec;57(12):993-7. doi: 10.1016/s0014-827x(02)01287-9.
7
Microwave-assisted synthesis and anti-HIV activity of new acyclic C-nucleosides of 3-(D-ribo-tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1.3-(D-核糖四醇-1-基)-5-巯基-1,2,4-三唑新型无环碳核苷的微波辅助合成及抗HIV活性。第1部分。
Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):469-83. doi: 10.1080/15257770802088829.
8
Synthesis and antiviral activity of 1,5- and 1,3-dialkyl-1,2,4-triazole C-nucleosides derived from 1-(chloroalkyl)-1-aza-2-azoniaallene salts.源自1-(氯烷基)-1-氮杂-2-氮鎓丙二烯盐的1,5-和1,3-二烷基-1,2,4-三唑C-核苷的合成及抗病毒活性
Nucleosides Nucleotides. 1999 Sep;18(9):1985-94. doi: 10.1080/07328319908044859.
9
Synthesis and evaluation of novel 6',6'-difluoro 5'-deoxycarbocyclic phosphonic acid nucleosides as antiviral agents.新型6',6'-二氟5'-脱氧碳环膦酸核苷作为抗病毒药物的合成与评价
Nucleosides Nucleotides Nucleic Acids. 2013;32(7):396-410. doi: 10.1080/15257770.2013.797582.
10
Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.合成新型 2'-脱氧-2'-氟-4'-叠氮核苷类似物作为有效的抗 HIV 药物。
Eur J Med Chem. 2011 Sep;46(9):4178-83. doi: 10.1016/j.ejmech.2011.06.020. Epub 2011 Jun 23.

引用本文的文献

1
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.以磺胺为先导结构开发的无环氮杂核苷的合成及抗病毒评价
Bioorg Med Chem. 2008 Sep 15;16(18):8379-89. doi: 10.1016/j.bmc.2008.08.041. Epub 2008 Aug 26.