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1
Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.用于研究人脆性组氨酸三联体蛋白Fhit的两种对水解酶具有抗性的5',5"'-P1,P3-三磷酸二腺苷类似物。
Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):301-8. doi: 10.1080/07328319808005178.
2
Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase.将人源二磷酸腺苷水解酶Fhit工程改造为高效的二核苷多磷酸合酶。
J Am Chem Soc. 2004 Aug 11;126(31):9548-9. doi: 10.1021/ja0400640.
3
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.Fhit是一种人类中的假定肿瘤抑制因子，是一种二核苷5'，5''-P1，P3-三磷酸水解酶。
Biochemistry. 1996 Sep 10;35(36):11529-35. doi: 10.1021/bi961415t.
4
Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases.两种特异性人二核苷多磷酸水解酶对2'-腺苷酸化的三磷酸二腺苷和四磷酸二腺苷（Ap(3)A和Ap(4)A）的选择性降解
Arch Biochem Biophys. 2000 Jan 1;373(1):218-24. doi: 10.1006/abbi.1999.1556.
5
T4 DNA ligase synthesizes dinucleoside polyphosphates.T4 DNA连接酶合成二核苷多磷酸。
FEBS Lett. 1998 Aug 21;433(3):283-6. doi: 10.1016/s0014-5793(98)00932-6.
6
New interactions between tumor suppressor Fhit protein and a nonhydrolyzable analog of its A A substrate.肿瘤抑制因子Fhit蛋白与其AA底物的不可水解类似物之间的新相互作用。
FEBS Lett. 2017 Feb;591(3):548-559. doi: 10.1002/1873-3468.12560. Epub 2017 Feb 5.
7
Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT.由酿酒酵母中人类FHIT类似物APH1对5',5'-二核苷三磷酸分解代谢的调控。
J Bacteriol. 1998 May;180(9):2345-9. doi: 10.1128/JB.180.9.2345-2349.1998.
8
The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate.脆性组氨酸三联体（Fhit）肿瘤抑制蛋白可调节细胞内三磷酸二腺苷的浓度，但不调节四磷酸二腺苷的浓度。
Cancer Res. 2000 May 1;60(9):2342-4.
9
Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX.脆性组氨酸三联体（Fhit）肿瘤抑制突变体形式在大肠杆菌中的表达、一步简单纯化及其与原卟啉IX的相互作用
Biotechnol Lett. 2007 Jun;29(6):877-83. doi: 10.1007/s10529-007-9322-9. Epub 2007 Feb 20.
10
The presence of diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) in human platelets.人血小板中5',5'''-P1,P3-三磷酸二腺苷（Ap3A）的存在。
Biochem Biophys Res Commun. 1983 Aug 30;115(1):253-60. doi: 10.1016/0006-291x(83)90997-x.

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1
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate.化学蛋白质组学分析揭示了警报素二腺苷三磷酸和四磷酸的蛋白质相互作用物。
Nat Commun. 2021 Oct 4;12(1):5808. doi: 10.1038/s41467-021-26075-4.
2
Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.迈向具有卓越翻译活性的mRNA：具有单个硫代磷酸酯修饰的ARCA四磷酸盐的合成与性质
New J Chem. 2010 Jan 1;34(5):993-1007. doi: 10.1039/b9nj00644c.
3
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.设计的FHIT等位基因表明，Fhit诱导的癌细胞凋亡受底物结合的限制。
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1592-7. doi: 10.1073/pnas.0437915100. Epub 2003 Feb 6.
4
Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.Hint、Fhit和GalT：核苷酸水解酶和转移酶的组氨酸三联体超家族三个分支的功能、结构、进化及作用机制
Biochemistry. 2002 Jul 23;41(29):9003-14. doi: 10.1021/bi025942q.
5
Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.二、三、四 - 5'-O-硫代磷酸腺苷取代的多元醇作为Fhit抑制剂：α-β桥连氧和β位磷取代的重要性。
BMC Chem Biol. 2001;1(1):3. doi: 10.1186/1472-6769-1-3.
6
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates.用新型荧光和荧光底物探测Fhit核苷酸特异性。
J Biol Chem. 2000 Feb 18;275(7):4555-60. doi: 10.1074/jbc.275.7.4555.
7
The histidine triad superfamily of nucleotide-binding proteins.核苷酸结合蛋白的组氨酸三联体超家族。
J Cell Physiol. 1999 Nov;181(2):179-87. doi: 10.1002/(SICI)1097-4652(199911)181:2<179::AID-JCP1>3.0.CO;2-8.
8
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.作为Fhit活性信号形式的Fhit-底物复合物的遗传、生化和晶体学特征。
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5484-9. doi: 10.1073/pnas.95.10.5484.
9
Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.模拟脆性组氨酸三联体蛋白活性状态的复合物的纯化与结晶
Protein Eng. 1997 Dec;10(12):1461-3. doi: 10.1093/protein/10.12.1461.

本文引用的文献

1
The occurrence of P1, P4-diguanosine 5'-tetraphosphate in brine shrimp eggs.虾卵中P1，P4-二鸟苷5'-四磷酸的存在情况。
J Biol Chem. 1963 Jan;238:344-8.
2
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.作为Fhit活性信号形式的Fhit-底物复合物的遗传、生化和晶体学特征。
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5484-9. doi: 10.1073/pnas.95.10.5484.
3
Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.模拟脆性组氨酸三联体蛋白活性状态的复合物的纯化与结晶
Protein Eng. 1997 Dec;10(12):1461-3. doi: 10.1093/protein/10.12.1461.
4
Cloning and expression of diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L.来自窄叶羽扇豆的二腺苷5',5'''-P1,P4-四磷酸水解酶的克隆与表达
Biochem J. 1998 Jan 15;329 ( Pt 2)(Pt 2):313-9. doi: 10.1042/bj3290313.
5
P1,P4-dithio-P2,P3-monochloromethylene diadenosine 5',5'''-P1,P4-tetraphosphate: a novel antiplatelet agent.P1,P4-二硫代-P2,P3-亚甲基二氯腺苷5',5'''-P1,P4-四磷酸：一种新型抗血小板药物。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4034-9. doi: 10.1073/pnas.94.8.4034.
6
Structure and expression of the human FHIT gene in normal and tumor cells.
Cancer Res. 1997 Feb 1;57(3):504-12.
7
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.Fhit是一种人类中的假定肿瘤抑制因子，是一种二核苷5'，5''-P1，P3-三磷酸水解酶。
Biochemistry. 1996 Sep 10;35(36):11529-35. doi: 10.1021/bi961415t.
8
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.FHIT基因跨越染色体3p14.2易碎位点和肾癌相关的t(3;8)断点，在消化道癌症中存在异常。
Cell. 1996 Feb 23;84(4):587-97. doi: 10.1016/s0092-8674(00)81034-x.
9
Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family.粟酒裂殖酵母中编码5',5'''-P1,P4-四磷酸二腺苷（Ap4A）不对称水解酶的基因克隆：与组氨酸三联体（HIT）蛋白家族的序列相似性
Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):925-32. doi: 10.1042/bj3120925.
10
Regiospecificity of the hydrolysis of diadenosine polyphosphates catalyzed by three specific pyrophosphohydrolases.三种特异性焦磷酸水解酶催化的二腺苷多磷酸水解的区域特异性
Biochemistry. 1994 Jan 11;33(1):235-40. doi: 10.1021/bi00167a031.

用于研究人脆性组氨酸三联体蛋白Fhit的两种对水解酶具有抗性的5',5"'-P1,P3-三磷酸二腺苷类似物。

Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.

作者信息

Blackburn G M, Liu X, Rösler A, Brenner C

机构信息

Department of Chemistry, Sheffield University, UK.

出版信息

Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):301-8. doi: 10.1080/07328319808005178.

DOI:10.1080/07328319808005178
PMID:9708352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2556045/
Abstract

The design and synthesis of analogues of diadenosine 5',5"'-P1,P3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.

摘要

本文描述了5',5'''-P1,P3-三磷酸二腺苷类似物的设计与合成，这些类似物对焦磷酸水解具有抗性，并阐述了它们在涉及Fhit蛋白（人类脆性组氨酸三联体蛋白，一种新型Ap3A结合/裂解蛋白）的信号传导和肿瘤发生中的作用。