用于研究人脆性组氨酸三联体蛋白Fhit的两种对水解酶具有抗性的5',5"'-P1,P3-三磷酸二腺苷类似物。
Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.
作者信息
Blackburn G M, Liu X, Rösler A, Brenner C
机构信息
Department of Chemistry, Sheffield University, UK.
出版信息
Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):301-8. doi: 10.1080/07328319808005178.
Abstract
The design and synthesis of analogues of diadenosine 5',5"'-P1,P3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.
摘要
本文描述了5',5'''-P1,P3-三磷酸二腺苷类似物的设计与合成，这些类似物对焦磷酸水解具有抗性，并阐述了它们在涉及Fhit蛋白（人类脆性组氨酸三联体蛋白，一种新型Ap3A结合/裂解蛋白）的信号传导和肿瘤发生中的作用。
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