Structurally altered substrates for DNA topoisomerase I. Effects of inclusion of a single 3'-deoxynucleotide within the scissile strand.
作者信息
Arslan T, Abraham A T, Hecht S M
机构信息
Department of Chemistry, University of Virginia, Charlottesville 22901, USA.
出版信息
Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):515-30. doi: 10.1080/07328319808005195.
PMID:9708360
Abstract
A partial DNA duplex containing a high efficiency topoisomerase I cleavage site was substituted singly at each of three sites with 3'-deoxyadenosine. Depending on the site of substitution, the facility of the topoisomerase I-mediated cleavage or ligation reactions was altered. Inclusion of the modified nucleoside at the 5'-end of the acceptor oligonucleotide diminished the rate of religation following substrate cleavage by the enzyme.
摘要
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