Wilhelm C, Keck C, Hess S, Korinthenberg R, Breckwoldt M
Department of Obstetrics and Gynecology, University Hospital Freiburg, Germany.
Fetal Diagn Ther. 1998 May-Jun;13(3):162-6. doi: 10.1159/000020830.
During the last 8 years in our department, fetal ventriculomegaly was diagnosed by prenatal ultrasound in 105 cases. Ventriculomegaly was detected at 25+/-6 weeks of gestation. In 96 of 105 cases follow-up examinations have been performed both during pregnancy and after delivery. In 47 cases termination of pregnancy, late spontaneous abortion or intrauterine death occurred. 49 cases resulted in live births. Of these, 28 children could be followed up to the age of 36 months, a few children even longer. Myelomeningocele was the most frequent cause of ventriculomegaly (17 cases = 61%). Insertion of ventricular shunt systems was performed in 26 children at a median of 21 days of life. Analysis of postnatal development was performed by the Kaufmann Assessment Battery for Children, or the Munich Functional Development Test. Correlation analysis was performed between parameters of prenatal findings and postnatal development. It could be shown that results of single prenatal ultrasound examinations did not correlate with postnatal development whereas progression of ventriculomegaly was negatively correlated with mental development.
在过去8年里，我们科室通过产前超声诊断出105例胎儿脑室扩大。脑室扩大在妊娠25±6周时被检测到。105例中的96例在孕期和产后均进行了随访检查。47例发生了终止妊娠、晚期自然流产或宫内死亡。49例分娩出活婴。其中，28名儿童被随访至36个月龄，少数儿童随访时间更长。脊髓脊膜膨出是脑室扩大最常见的原因（17例=61%）。26名儿童在出生后中位数21天时进行了脑室分流系统植入。通过考夫曼儿童评估量表或慕尼黑功能发育测试对产后发育进行分析。对产前检查结果参数与产后发育进行相关性分析。结果显示，单次产前超声检查结果与产后发育无相关性，而脑室扩大的进展与智力发育呈负相关。
