Carpentier A, Jeannotte S, Verreault J, Lefebvre B, Bisson G, Mongeau C J, Maheux P
Department of Medicine, Faculté de Médecine, Université de Sherbrooke, Québec, Canada.
J Nucl Med. 1998 Aug;39(8):1441-4.
The aim of this study was to assess the relationship between parathyroid oxyphil cell content and early or late phases of uptake of 99mTc-MIBI, a radioisotope preferentially retained in mitochondria-rich cells.
This study is a retrospective, single-blind analysis of all double-phase 99mTc-MIBI parathyroid scintigraphy studies performed before surgery in our institution between 1990 and 1995. A total of 18 parathyroid lesions in 14 patients were reviewed. This sample included 11 cases of primary hyperparathyroidism (8 adenomas, 1 adenocarcinoma and 2 hyperplasias) and 3 cases of tertiary hyperparathyroidism secondary to chronic renal failure.
Uptake of 99mTc-MIBI in the early phase of scintigraphy was associated with larger parathyroid lesions (1.61 +/- 1.61 ml versus 0.33 +/- 0.27 ml; p < 0.02) and higher serum calcium levels (3.00 +/- 0.41 mM versus 2.67 +/- 0.14 mM; p < 0.02). More importantly, we found that a parathyroid oxyphil cell content greater than 25% was more often associated with a positive uptake of 99mTc-MIBI in the late phase of the test (positive late uptake in 78% of lesions with a high oxyphil cell content versus 33% in lesions with an oxyphil cell content between 1% and 25% and 0% in lesions with no oxyphil cells; p < 0.04).
These findings suggest that the late retention of 99mTc-MIBI in double-phase scintigraphy is related to parathyroid oxyphil cell content.
本研究的目的是评估甲状旁腺嗜酸性细胞含量与99mTc-MIBI摄取的早期或晚期之间的关系，99mTc-MIBI是一种优先保留在富含线粒体细胞中的放射性同位素。
本研究是对1990年至1995年间在本机构进行手术前的所有双相99mTc-MIBI甲状旁腺闪烁扫描研究进行的回顾性单盲分析。共回顾了14例患者的18个甲状旁腺病变。该样本包括11例原发性甲状旁腺功能亢进（8例腺瘤、1例腺癌和2例增生）和3例继发于慢性肾功能衰竭的三发性甲状旁腺功能亢进。
闪烁扫描早期99mTc-MIBI的摄取与较大甲状旁腺病变相关（1.61±1.61 ml对0.33±0.27 ml；p<0.02）以及较高的血清钙水平（3.00±0.41 mM对2.67±0.14 mM；p<0.02）。更重要的是，我们发现甲状旁腺嗜酸性细胞含量大于25%更常与检查后期99mTc-MIBI的阳性摄取相关（嗜酸性细胞含量高的病变中78%后期摄取阳性，嗜酸性细胞含量在1%至25%之间的病变中为33%，无嗜酸性细胞的病变中为0%；p<0.04）。
这些发现表明双相闪烁扫描中99mTc-MIBI的后期滞留与甲状旁腺嗜酸性细胞含量有关。
