Hwang I, Balingit A G, Georgitis W J, Sisson J C, Shapiro B
Nuclear Medicine Service, Walter Reed Medical Center, Washington, DC 20307-5001, USA.
J Nucl Med. 1998 Aug;39(8):1460-3.
Adrenal scintigraphy with 131I-labeled 6-beta-iodomethyl-19-norcholesterol (NP-59) is a technically demanding and complex procedure. However, it can provide crucial and unique information about the functional status of the adrenal glands and guide the appropriate therapeutic management of patients with biochemically proven disease. Since the introduction of this new investigational drug, scintigraphic imaging has been performed using conventional planar techniques. We present an interesting case of primary aldosteronism in which planar scintigraphy and SPECT were combined in an attempt to increase the sensitivity of the study. SPECT revealed scintigraphic evidence of bilateral adrenocortical hyperplasia. Interestingly, the CT scan of this patient showed only an equivocal abnormality in the left adrenal gland, suggestive of an adenoma.
用131I标记的6-β-碘甲基-19-去甲胆固醇（NP-59）进行肾上腺闪烁显像是一项技术要求高且复杂的操作。然而，它可以提供有关肾上腺功能状态的关键且独特的信息，并指导对经生化证实疾病患者的适当治疗管理。自从引入这种新的研究药物以来，闪烁显像一直使用传统的平面技术进行。我们报告了一例原发性醛固酮增多症的有趣病例，其中将平面闪烁显像和单光子发射计算机断层扫描（SPECT）相结合，试图提高研究的敏感性。SPECT显示双侧肾上腺皮质增生的闪烁显像证据。有趣的是，该患者的CT扫描仅显示左肾上腺有可疑异常，提示腺瘤。
