Asbury R, Blessing J A, Reid G C, McGuire W P
Department of Medicine in Oncology, University of Rochester School of Medicine, New York, USA.
Am J Clin Oncol. 1998 Aug;21(4):406-7. doi: 10.1097/00000421-199808000-00018.
Twenty-nine evaluable patients with endometrial cancer were treated with amonafide 300 mg/m2 for 5 consecutive days every 3 weeks. Two partial responses (8%) were seen. Hematologic toxicity was severe or life-threatening in 13 patients occurring as follows: leukopenia in 13 patients (45%); thrombocytopenia in 10 patients (34%); granulocytopenia in 13 patients (45%); and anemia in four patients (14%). In view of the low response rate and high toxicity, this dose schedule of amonafide does not warrant further investigation in endometrial cancer.
