Kirk D L, Yates G K
Department of Physiology, University of Western Australia, Nedlands, Australia.
Neurosci Lett. 1998 Jul 10;250(3):149-52. doi: 10.1016/s0304-3940(98)00460-1.
ATP was iontophoresed into the scala media of the guinea pig cochlea. A reversible increase in the amplitude of electrically-evoked oto-acoustic emissions (EEOAEs), and reductions in the endocochlear potential (EP) and the cochlear microphonic (CM) were observed. These effects were consistent with an action of ATP on P2X receptors on outer hair cells (OHC). The results confirm that endogenous endolymphatic ATP, acting via P2X receptors on OHCs, may serve a regulatory function in the cochlea.
将三磷酸腺苷（ATP）通过离子电渗疗法导入豚鼠耳蜗的中阶。观察到电诱发耳声发射（EEOAE）的幅度出现可逆性增加，以及内淋巴电位（EP）和耳蜗微音电位（CM）降低。这些效应与ATP对外毛细胞（OHC）上P2X受体的作用一致。结果证实，内源性内淋巴ATP通过OHC上的P2X受体发挥作用，可能在耳蜗中起到调节功能。
