Morales-Betoulle M E, de la Salmonière Y O, Zwetyenga J, Le Scanf C, Jouin H, Michel J C
Laboratoire d'Immunologie Parasitaire, Institut Pasteur de Guyane, Cayenne Cédex, BP 6010, 97306, France.
Exp Parasitol. 1998 Sep;90(1):49-57. doi: 10.1006/expr.1998.4318.
Protective immunity against a Plasmodium falciparum blood infection can be passively transferred by antibodies in humans and in the primate experimental malaria model Saimiri sciureus. We report here the emergence of a novel virulent parasite population after such passive transfer of hyperimmune serum in splenectomized monkeys. These FUP-2 parasites have been partially genotyped and phenotyped. Although no genotypic variation was detected for four polymorphic loci compared to the original FUP-1 parasite population, FUP-2-infected erythrocytes exhibit little or no detectable surface determinants, including those reacting with antibodies raised against FUP-1 surface antigens. In addition, FUP-2-infected erythrocytes exhibit no rosetting or autoagglutination. Interestingly, although Saimiri monkeys control efficiently FUP-2 parasites after repetitive infections, this protection cannot be passively transferred to naive recipients. Our results suggest that antibody-mediated and antibody-independent T-cell-mediated protective responses may cooperate in controlling P. falciparum infection in splenectomized Saimiri monkeys.
在人类和灵长类实验性疟疾模型松鼠猴中，针对恶性疟原虫血液感染的保护性免疫可通过抗体进行被动转移。我们在此报告，在脾切除的猴子中进行这种超免疫血清的被动转移后，出现了一种新的毒性寄生虫群体。这些FUP - 2寄生虫已进行了部分基因分型和表型分析。与原始的FUP - 1寄生虫群体相比，四个多态性位点未检测到基因变异，但FUP - 2感染的红细胞几乎没有或没有可检测到的表面决定簇，包括那些与针对FUP - 1表面抗原产生的抗体发生反应的决定簇。此外，FUP - 2感染的红细胞不表现出凝集或自凝现象。有趣的是，尽管松鼠猴在反复感染后能有效控制FUP - 2寄生虫，但这种保护不能被动转移给未感染的受体。我们的结果表明，抗体介导的和不依赖抗体的T细胞介导的保护性反应可能协同控制脾切除的松鼠猴中的恶性疟原虫感染。
