Hreczuk-Hirst D, Rowell F J, Reeve R N, Cumming R H, Guest I
North East Biotechnology Centre, School of Health Sciences, University of Sunderland, UK.
Analyst. 1998 May;123(5):1121-6. doi: 10.1039/a708204e.
A simple and relatively rapid enzyme-linked immunosorbant assay method for the anti-emetic drug ondansetron has been developed for its quantitation in solution. This has been optimised for use with samples that have been obtained following extraction of filters after the drug's capture from air samples in the workplace. The assay has the sample throughput (40 duplicate samples in 3 h), specificity, sensitivity (LOD of 10.5 ng drug ml-1) and precision (RSD < 11%) necessary for its use in determining airborne concentrations of ondansetron in such samples as part of an occupational health and hygiene monitoring programme.
已开发出一种简单且相对快速的酶联免疫吸附测定方法，用于定量溶液中的止吐药物昂丹司琼。该方法已针对从工作场所空气样本中捕获药物后提取滤器所获得的样本进行了优化。该测定法具有样本通量（3小时内40个重复样本）、特异性、灵敏度（药物检测限为10.5纳克/毫升）和精密度（相对标准偏差<11%），这些是其作为职业健康与卫生监测计划的一部分，用于测定此类样本中昂丹司琼空气传播浓度所必需的。
