细胞色素P-450血红素与肝脏血红素加氧酶活性的调节 - Suppr

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Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity.

作者信息

Bissell D M, Hammaker L E

出版信息

Arch Biochem Biophys. 1976 Sep;176(1):91-102. doi: 10.1016/0003-9861(76)90144-2.

DOI:10.1016/0003-9861(76)90144-2

PMID:970967

Abstract

摘要

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Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity.细胞色素P-450血红素与肝脏血红素加氧酶活性的调节

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Cyclic oscillations in rat hepatic heme oxygenase and delta-aminolevulinic acid synthetase following intravenous heme administration.静脉注射血红素后大鼠肝脏血红素加氧酶和δ-氨基乙酰丙酸合成酶的周期性振荡

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The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase.痕量金属对各种组织中血红素氧化的诱导作用：肝脏血红素加氧酶对内源性血红素进行分解代谢的证据。

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Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls.微粒体血红素加氧酶对多氯联苯诱导的细胞色素P-448的分解代谢证据，以及多氯联苯对δ-氨基乙酰丙酸脱水酶的抑制作用。

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Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells.细胞色素 P450 2B1 基因沉默可减轻嘌呤霉素氨基核苷诱导的肾小球上皮细胞毒性。

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The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo.血红素加氧酶-1在体内预防急性血红素蛋白诱导的毒性中的不可或缺性。

Am J Pathol. 2000 May;156(5):1527-35. doi: 10.1016/S0002-9440(10)65024-9.

Participation of altered upstream stimulatory factor in the induction of rat heme oxygenase-1 by cadmium.改变的上游刺激因子参与镉诱导大鼠血红素加氧酶-1的过程。

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Cytokine induction of haem oxygenase mRNA in mouse liver. Interleukin 1 transcriptionally activates the haem oxygenase gene.细胞因子诱导小鼠肝脏中血红素加氧酶mRNA的表达。白细胞介素1转录激活血红素加氧酶基因。

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Effects of age, phenobarbital, beta-naphthoflavone and dexamethasone on rat hepatic heme oxygenase.年龄、苯巴比妥、β-萘黄酮及地塞米松对大鼠肝脏血红素加氧酶的影响

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Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.一氧化氮是免疫刺激剂引起的细胞色素P450依赖性代谢降低的介质。

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Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.内源性肝血红素通过不产生一氧化碳的途径进行降解。对正常大鼠肝脏和原代肝细胞培养的研究。

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Tryptophan pyrrolase in haem regulation. Experiments with administered haematin and the relationship between the haem saturation of tryptophan pyrrolase and the activity of 5-aminolaevulinate synthase in rat liver.血红素调节中的色氨酸吡咯酶。关于给予高铁血红素的实验以及大鼠肝脏中色氨酸吡咯酶的血红素饱和度与5-氨基乙酰丙酸合酶活性之间的关系。

Biochem J. 1980 Nov 15;192(2):403-10. doi: 10.1042/bj1920403.

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