硫酸脱氢表雄酮治疗强直性肌营养不良的一项初步研究。

A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy.

作者信息

Sugino M, Ohsawa N, Ito T, Ishida S, Yamasaki H, Kimura F, Shinoda K

机构信息

First Department of Internal Medicine, Osaka Medical College, Takatsuki-City, Japan.

出版信息

Neurology. 1998 Aug;51(2):586-9. doi: 10.1212/wnl.51.2.586.

DOI:10.1212/wnl.51.2.586

PMID:9710041

Abstract

We studied the effect of i.v. administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients with myotonic dystrophy (MyD). After DHEAS, activities of daily living improved, muscle strength increased, and myotonia decreased. Conduction block and premature beats also improved in the four patients with cardiac involvement. This pilot study may provide a rationale for a controlled study of DHEAS in MyD.

摘要

我们研究了静脉注射硫酸脱氢表雄酮（DHEAS）制剂（200毫克/天，共8周）对11例强直性肌营养不良（MyD）患者的影响。使用DHEAS后，患者的日常生活活动能力得到改善，肌肉力量增强，肌强直减轻。在4例有心脏受累的患者中，传导阻滞和早搏也有所改善。这项初步研究可能为对强直性肌营养不良患者进行DHEAS对照研究提供理论依据。