Gordon M Y, Blackett N M
Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Cell Transplant. 1998 Jul-Aug;7(4):339-44. doi: 10.1177/096368979800700401.
The practice of hematopoietic stem cell transplantation to rescue patients from the myeloablative effects of chemo- or radiotherapy, or to replace defective hematopoiesis, is based on the assumption that hematopoietic stem cells in the graft have sufficient proliferative potential to supply mature blood cells for the remainder of the recipient's lifespan. However, the mechanism(s) whereby this is achieved are not well understood. Here we address the reconstruction of the hematopoietic system by considering the effects of stem cell and progenitor cell renewal and differentiation. We conclude that stem cell self-renewal is necessary for hematological recovery and that infused committed progenitor cells (CFU-GM) may contribute to the neutrophil count in the early posttransplant period.
造血干细胞移植用于挽救因化疗或放疗的清髓作用而受损的患者，或替代有缺陷的造血功能，其依据的假设是移植物中的造血干细胞具有足够的增殖潜力，能够在受体的余生中提供成熟血细胞。然而，实现这一目标的机制尚不清楚。在这里，我们通过考虑干细胞和祖细胞更新与分化的影响来探讨造血系统的重建。我们得出结论，干细胞自我更新对于血液学恢复是必要的，并且输注的定向祖细胞（CFU-GM）可能在移植后早期对中性粒细胞计数有贡献。
