Kunt T, Forst T, Harzer O, Buchert G, Pfützner A, Löbig M, Zschäbitz A, Stofft E, Engelbach M, Beyer J
Department of Internal Medicine and Endocrinology, University of Mainz, Germany.
Exp Clin Endocrinol Diabetes. 1998;106(3):183-8. doi: 10.1055/s-0029-1211974.
Advanced glycation endproducts (AGEs) possibly play a dominant role in the pathogenesis of macrovascular disease in diabetes. Recent studies could demonstrate that glycated albumin (AGE-BSA) was able to stimulate vascular cell adhesion molecule-1 (VCAM.1) on endothelial cells. The aim of this study was to find out if AGE-BSA was not only able to enhance the expression of vascular cell adhesion molecule-1, but also of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin on human endothelial cells. Stimulation of endothelial cells with AGE-BSA for six hours predominantly increased the expression of VCAM-1, but ICAM-1 and E-Selectin were also upregulated as shown by immunoilluminometric assay (ILMA).
