几种计算肥胖儿童基础代谢率方程的比较及新方程的推导

Comparison of several equations and derivation of a new equation for calculating basal metabolic rate in obese children.

作者信息

Tverskaya R, Rising R, Brown D, Lifshitz F

机构信息

Maimonides Medical Center Department of Pediatrics, Brooklyn, New York, USA.

出版信息

J Am Coll Nutr. 1998 Aug;17(4):333-6. doi: 10.1080/07315724.1998.10718771.

DOI:10.1080/07315724.1998.10718771

PMID:9710841

Abstract

OBJECTIVES

To compare basal metabolic rate (BMR) calculated by the Harris-Benedict, Ravussin, Cunningham, World Health Organization (WHO) and Schofield equations to BMR determined in an obese pediatric population. The second objective is to derive a new equation, based on measured BMR in obese children, for calculating BMR in obese pediatric patients.

METHODS

The study included 110 (50 male/60 female) healthy obese subjects (BMI > 28) (11.7 +/- 2.8 years, 73 +/- 27 kg, 152 +/- 14 cm and 38 +/- 6% fat) who had preprandial BMR determined by indirect calorimetry. These results were compared to BMR calculated with the five above mentioned equations. Fat-free mass was determined by bioelectrical impedance and body composition was calculated using the appropriate equation. The age groups analyzed were as follows: males 3 to 10 and 11 to 18 years old; females 3 to 10 and 11 to 18 years old. A new equation was derived by stepwise multiple regression analysis using 100 randomly selected subjects from our test group and tested using the remaining 10 subjects.

RESULTS

Basal metabolic rate calculated by the Ravussin and Cunningham equations in all subgroups was lower (p < 0.05) than measured BMR. Basal metabolic rate calculated by the Harris-Benedict equation was lower (p < 0.05) than measured BMR in male populations ages 3 to 10, 11 to 18, and in the entire cohort. Measured BMR was overestimated by the Harris-Benedict equation (p < 0.05) in females 11 to 18 years old; by the WHO equation (p < 0.05) in both male and females 3 to 10 years old and by the Schofield equation (p < 0.05) in males 11 to 18 years old. In comparison to measured BMR, the WHO equation appeared to be the most accurate for estimating BMR in males and females 11 to 18 years old. However, BMR calculating using our new equation in the 10 test subjects was similar to measured BMR.

CONCLUSIONS

The WHO equation was the most accurate of the prediction equations studied. However, our new prediction equation may be more appropriate for calculating BMR in an obese pediatric population.

摘要

目的

比较通过哈里斯-本尼迪克特方程、拉武辛方程、坎宁安方程、世界卫生组织（WHO）方程和斯科菲尔德方程计算出的基础代谢率（BMR）与在肥胖儿科人群中测定的BMR。第二个目的是基于肥胖儿童中测得的BMR推导一个新方程，用于计算肥胖儿科患者的BMR。

方法

该研究纳入了110名（50名男性/60名女性）健康肥胖受试者（BMI>28）（年龄11.7±2.8岁，体重73±27千克，身高152±14厘米，体脂率38±6%），通过间接测热法测定其餐前BMR。将这些结果与用上述五个方程计算出的BMR进行比较。通过生物电阻抗法测定去脂体重，并使用适当的方程计算身体成分。分析的年龄组如下：男性3至10岁和11至18岁；女性3至10岁和11至18岁。使用从测试组中随机选择的100名受试者通过逐步多元回归分析推导出一个新方程，并使用其余10名受试者进行测试。

结果

在所有亚组中，通过拉武辛方程和坎宁安方程计算出的基础代谢率均低于测得的BMR（p<0.05）。在3至10岁、11至18岁的男性人群以及整个队列中，通过哈里斯-本尼迪克特方程计算出的基础代谢率低于测得的BMR（p<0.05）。在11至18岁的女性中，哈里斯-本尼迪克特方程高估了测得的BMR（p<0.05）；在3至10岁的男性和女性中，WHO方程高估了测得的BMR（p<0.05）；在11至18岁的男性中，斯科菲尔德方程高估了测得的BMR（p<0.05）。与测得的BMR相比，WHO方程似乎是估算11至18岁男性和女性BMR最准确的方程。然而，在10名测试受试者中，使用我们的新方程计算出的BMR与测得的BMR相似。