Breedveld F C
Department of Rheumatology, Leiden University Medical Center, The Netherlands.
Rheum Dis Clin North Am. 1998 Aug;24(3):567-78. doi: 10.1016/s0889-857x(05)70026-0.
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including collagen-induced arthritis.
