Nomura M, Nakaya Y, Nada T, Endo J, Kondo Y, Yukinaka M, Saito K, Ito S
Second Department of Internal Medicine, University of Tokushima, Japan.
Jpn Heart J. 1998 May;39(3):331-8. doi: 10.1536/ihj.39.331.
We studied the differences between isosorbide dinitrate (ISDN) and L-arginine (L-Arg), the precursor of nitric oxide, regarding autonomic nervous function by assessing changes in heart rate variability and blood levels of various vasoactive substances. Healthy volunteers received infused L-arginine (L-Arg group) or isosorbide dinitrate (ISDN group). ECGs were monitored and analyzed. Blood levels of catecholamines, endothelin, renin activity, angiotensin, human atrial natriuretic peptide, aldosterone, arginine, and citrulline were examined. Time-domain analyses of heart rate variability showed no significant changes in occurrence of R-R variability or coefficient of R-R variability, indicators of parasympathetic activity, after administration of ISDN. By contrast, both measures showed significantly more variation following administration of L-Arg. Frequency-domain analyses showed that high frequency power, an indicator of parasympathetic activity, was significantly elevated in the L-Arg group, whereas there was no significant change in the ISDN group. The blood levels of the measured vasoactive substances in L-Arg and ISDN groups were significantly different. The differences in autonomic nervous function and various kinds of vasoactive substances between the L-Arg and ISDN groups suggest that L-Arg had other actions on humoral factors in addition to vasodilation. Thus, arginine/nitric oxide may act as a neurotransmitter, altering parasympathetic nervous tension.
我们通过评估心率变异性和各种血管活性物质的血液水平变化，研究了硝酸异山梨酯（ISDN）与一氧化氮前体L-精氨酸（L-Arg）在自主神经功能方面的差异。健康志愿者接受了L-精氨酸输注（L-Arg组）或硝酸异山梨酯（ISDN组）。监测并分析心电图。检测儿茶酚胺、内皮素、肾素活性、血管紧张素、人心房利钠肽、醛固酮、精氨酸和瓜氨酸的血液水平。心率变异性的时域分析显示，ISDN给药后，作为副交感神经活动指标的R-R变异性发生率或R-R变异系数没有显著变化。相比之下，L-Arg给药后这两项指标均显示出显著更多的变化。频域分析表明，作为副交感神经活动指标的高频功率在L-Arg组显著升高，而ISDN组没有显著变化。L-Arg组和ISDN组中所测血管活性物质的血液水平有显著差异。L-Arg组和ISDN组在自主神经功能和各种血管活性物质方面的差异表明，L-Arg除血管舒张作用外，对体液因子还有其他作用。因此，精氨酸/一氧化氮可能作为一种神经递质，改变副交感神经张力。
